Oestrogen Receptor

This table contains entries for the oestrogen receptors in the UniProt database, as well as for the oestrogen-related proteins and the other members of the nuclear receptor family. Links are provided to view the original protein entries. The proteins used to construct the signature for IPR001292 are given with links to the relevant databases.

	Family	UniProt	Protein name	Organism	Natural Ligand	Function	Disease Association
Oestrogen receptor	3A	ESR1_HUMAN (P03372)	Oestrogen receptor	Homo sapiens	17beta-estradiol	Female fertility; bone mineralisation; brain function; cardiovascular function; lipid and carbohydrate metabolism	Breast cancer; Osteoporosis; Endometriosis
		ESR2_HUMAN (Q92731)	Oestrogen receptor beta	Homo sapiens	17beta-estradiol	Female and male fertility; bone mineralisation; brain function; cardiovascular function; lipid and carbohydrate metabolism	Breast cancer; Osteoporosis; Endometriosis
Oestrogen-related receptors	3B	ERR1_HUMAN (P11474)	Steroid hormone receptor ERR1 (Oestrogen-related receptor, alpha)	Homo sapiens		Bone physiology; may act as a repressor of ER action in normal breast tissue
		ERR2_HUMAN (O95718)	Steroid hormone receptor ERR2 (Oestrogen-related receptor, beta)	Homo sapiens		Reproduction
		ERR3_HUMAN (O75454)	Oestrogen-related receptor gamma	Homo sapiens		Regulates expression SHP
Other nuclear receptors	1A	THA_HUMAN (P10827)	Thyroid hormone receptor alpha	Homo sapiens	triiodothyronine	Thermogenesis (brown adipose tissue); thyroid hormone function	Papular atrichia and alopecia universalis (hair loss disorders)
		THB1_HUMAN (P10828)	Thyroid hormone receptor beta-1	Homo sapiens	triiodothyronine	Auditory development; thyroid hormone regulation	Generalized thyroid hormone resistance; Papular atrichia and alopecia universalis
		THB2_HUMAN (P37243)	Thyroid hormone receptor beta-2	Homo sapiens	triiodothyronine
	1B	RRA_HUMAN (P10276)	Retinoic acid receptor alpha	Homo sapiens	9-cis or all-trans retinoic acid		Acute promyelocytic leukemia t(11;17), t(5;17), t(15:17)
		RRB_HUMAN (P10826)	Retinoic acid receptor beta	Homo sapiens	all-trans retinoic acid
		RRB1_HUMAN (Q9P2E9)	Ribosome-binding protein 1	Homo sapiens
		RRG1_HUMAN (P13631)	Retinoic acid receptor gamma-1	Homo sapiens	all-trans retinoic acid
		RRG2_HUMAN (P22932)	Retinoic acid receptor gamma-2	Homo sapiens
	1C	PPAR_HUMAN (Q07869)	Peroxisome proliferator activated receptor alpha	Homo sapiens	peroxisome proliferators: saturated and unsaturated fatty acids (palmitic acid, oleic acid, linoleic acid, arachidonic acid)	Beta-oxidation of fatty acids	Dyslipidemia; Atherosclerosis; Possibly obesity/diabetes
		PPAS_HUMAN (Q03181)	Peroxisome proliferator activated receptor delta	Homo sapiens	peroxisome proliferators: fatty acids	Peroxisomal beta-oxidation of fatty acids
		PPAT_HUMAN (P37231)	Peroxisome proliferator activated receptor gamma	Homo sapiens	peroxisome proliferators: fatty acids	Peroxisomal beta-oxidation of fatty acids; adipocyte differentiation; glucose homeostasis	Type 2 insulin-resistant diabetes and hypertension; Genetic predispositon to obesity
	1D	NRD1_HUMAN (P20393)	Orphan nuclear receptor NR1D1 (Rev-erbA-alpha)	Homo sapiens	possibly triiodothyronine
		NRD2_HUMAN (Q14995)	Orphan nuclear receptor NR1D2 (Rev-erb-beta)	Homo sapiens
		E75_METEN (O77245)	Nuclear hormone receptor E75	Metapenaeus ensis Greasyback shrimp		Regulation of ecdysone-triggered gene hierarchies
	1E	Q9NBW9	Nuclear receptor E78A	Drosophila melanogaster Fruit fly
	1F	RORA_HUMAN (P35398)	Nuclear receptor ROR-alpha	Homo sapiens		Hepatic gene regulation; Hypoxic stress response
		RORB_HUMAN (Q92753)	Nuclear receptor ROR-beta	Homo sapiens
		RORG_HUMAN (P51449)	Nuclear receptor ROR-gamma	Homo sapiens
		HR3_DROME (P31396)	Probable nuclear hormone receptor HR3	Drosophila melanogaster Fruit fly
	1G	CNRD_CAEEL (P41830)	Steroid hormone receptor family member cnr14	Caenorhabditis elegans Nematode worm
	1H	ECR_DROME (P34021)	Ecdysone receptor (Ecdysteroid receptor)	Drosophila melanogaster Fruit fly	Ecdysone
		NRH2_HUMAN (P55055)	Oxysterols receptor LXR-beta	Homo sapiens	Oxysterols (cholesterol metabolism)	Regulation of cholesterol homeostasis (sensor of dietary cholesterol in the liver)
		NRH3_HUMAN (Q13133)	Oxysterols receptor LXR-alpha	Homo sapiens	Oxysterols (cholesterol metabolism)	Regulation of cholesterol homeostasis (sensor of dietary cholesterol in the liver)
		NRH4_HUMAN (Q96RI1)	Bile acid receptor (Farnesoid X-activated receptor)	Homo sapiens	Bile acids	Regulation of cholesterol and bile acid homeostasis
	1I	VDR_HUMAN (P11473)	Vitamin D3 receptor	Homo sapiens	1,25-dihydroxy vitamin D3, 3-keto-lithocholic acid	Mediates vitamin D3 function	Type IIA rickets
		PXR_HUMAN (O75469)	Orphan nuclear receptor PXR (Pregnane X receptor)	Homo sapiens	Bile acids
		NRI3_HUMAN (Q14994)	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor)	Homo sapiens	Androgen metabolites, e.g.androsterol
	2A	HN4A_HUMAN (P41235)	Hepatocyte nuclear factor 4-alpha	Homo sapiens	C14-C18 fatty acids	Liver, kidney, intestine development	Monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I
		HN4G_HUMAN (Q14541)	Hepatocyte nuclear factor 4-gamma	Homo sapiens
		HNF4_DROME (P49866)	Transcription factor HNF-4 homolog	Drosophila melanogaster Fruit fly		Endodermal and mesodermal differentiation
		NH64_CAEEL (O44960)	Nuclear hormone receptor family member nhr-64	Caenorhabditis elegans Nematode worm
	2B	RXRA_HUMAN (P19793)	Retinoic acid receptor RXR-alpha	Homo sapiens	9-cis retinoic acid	Retinoic acid response pathway
		RXRB_HUMAN (P28702)	Retinoic acid receptor RXR-beta	Homo sapiens	9-cis retinoic acid	Retinoic acid response pathway
		RXRG_HUMAN (P48443)	Retinoic acid receptor RXR-gamma	Homo sapiens	9-cis retinoic acid	Retinoic acid response pathway
		USP_DROME (P20153)	Ultraspiracle protein	Drosophila melanogaster Fruit fly	Ecdysone
	2C	TR2_HUMAN (P13056)	Orphan nuclear receptor TR2	Homo sapiens
		TR4_HUMAN (P49116)	Orphan nuclear receptor TR4	Homo sapiens		Spermatogenesis gene expression
	2D	HR78_DROME (Q24142)	Nuclear hormone receptor HR78	Drosophila melanogaster Fruit fly		Inhibits ecdysone response
	2E	NR21_HUMAN (Q9Y466)	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX)	Homo sapiens		Retinal and brain development
		TLL_DROME (P18102)	Tailless protein	Drosophila melanogaster Fruit fly		Establishment of nonmetameric domains at anterior and posterior poles of embryo; eye development
		NR23_HUMAN (Q9Y5X4)	Photoreceptor-specific nuclear receptor	Homo sapiens		Photoreceptor cell function	Enhanced S Cone Syndrome
		O96680	Dissatisfaction	Drosophila melanogaster Fruit fly
	2F	COT1_HUMAN (P10589)	COUP transcription factor 1	Homo sapiens
		COT2_HUMAN (P24468)	COUP transcription factor 2	Homo sapiens
		EAR2_HUMAN (P10588)	Orphan nuclear receptor EAR-2	Homo sapiens
		7UP1_DROME (P16375)	Steroid receptor seven-up type 1	Drosophila melanogaster Fruit fly		Eye development
	3C	GCR_HUMAN (P04150)	Glucocorticoid receptor	Homo sapiens	Glucocorticoids (corticosterone or cortisol)		Familial Glucocorticoid Resistance
		MCR_HUMAN (P08235)	Mineralocorticoid receptor	Homo sapiens	Mineralocorticoids (aldosterone) and glucocorticoids	Mineralocorticoids increase ion and water transport raising blood pressure, and lower potassium levels
		PRGR_HUMAN (P06401)	Progesterone receptor	Homo sapiens	Progesterone	Fertility
		ANDR_HUMAN (P10275)	Androgen receptor	Homo sapiens	Testosterone	Fertility; vascular function; bone mineralisation; lipid and carbohydrate metabolism	Androgen Insensitivity Síndrome; X-linked Spinal and Bulbar Muscular Atrophy; Metastatic Prostate Cancer; Infertility Male Syndrome
	4A	NR41_HUMAN (P22736)	Orphan nuclear receptor HMR	Homo sapiens
		NR42_HUMAN (P43354)	Orphan nuclear receptor NURR1	Homo sapiens
		NR43_HUMAN (Q92570)	Nuclear hormone receptor NOR-1	Homo sapiens			Ewing's Sarcoma t(9;22); Extraskeletal Myxoid Chondrosarcomas t(9;17)
		HR38_DROME (P49869)	Probable nuclear hormone receptor HR38	Drosophila melanogaster Fruit fly
		NHR6_CAEEL (P41829)	Nuclear hormone receptor family member nhr-6	Caenorhabditis elegans Nematode worm
	5A	STF1_HUMAN (Q13285)	Steroidogenic factor 1	Homo sapiens		Sexual differentiation and formation steroidogenic tissues	XY sex reversal
		NR52_HUMAN (O00482)	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor)	Homo sapiens		Embryonic development
		FTF1_DROME (P33244)	Nuclear hormone receptor FTZ-F1	Drosophila melanogaster Fruit fly
	5B	FTFB_DROME (Q05192)	Nuclear hormone receptor FTZ-F1 beta	Drosophila melanogaster Fruit fly
	6A	NR61_HUMAN (Q15406)	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor, GCNF)	Homo sapiens
	0A	KNIR_DROME (P10734)	Zygotic gap protein knirps	Drosophila melanogaster Fruit fly
		KNRL_DROME (P13054)	Knirps-related protein	Drosophila melanogaster Fruit fly
		TRX_DROME (P20659)	Trithorax protein	Drosophila melanogaster Fruit fly
	0B	DAX1_HUMAN (P51843)	Orphan nuclear receptor DAX-1	Homo sapiens		Development of steroidogenic tissues	X-linked Adrenal Hypoplasia Congenita; Hypogonadotrophic Hypogonadism
		SHP_HUMAN (Q15466)	Orphan nuclear receptor SHP (Small heterodimer partner)	Homo sapiens		Negative regulator of receptor-dependent signalling pathways

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