SV40

 

            This table contains entries for SV40 viral proteins in the UniProt databases, with links to view the original protein entries.  There is also a list of some of the proteins known to interact with, be induced by or repressed by SV40 proteins.

 

 

UniProt

Protein name

Organism

Function

 

COA1_SV40 (P03087)

Coat protein VP1

Simian virus 40

(SV40)

Forms part of viral capsid

 

COA2_SV40 (P03093)

Coat protein VP2

(contains Coat protein VP3)

Simian virus 40

(SV40)

Forms part of viral capsid

 

O92837

Coat protein VP3

Simian virus 40

(SV40)

Forms part of viral capsid

 

DNBI_SV40 (P03084)

DNA-binding protein

(Agnoprotein)

Simian virus 40

(SV40)

May have regulatory role in nucleic acid-protein interactions

 

TALA_SV40 (P03070)

Large T antigen

Simian virus 40

(SV40)

Initiates DNA unwinding and replication

 

TASM_SV40 (P03081)

Small T antigen

Simian virus 40

(SV40)

 

 

Q04240

Early leader protein (SELP)

Simian virus 40

(SV40)

 

SV40-induced

NGAL_MOUSE (P11672)

Neutrophil gelatinase-associated lipocalin [Precursor] (SV-40 induced 24P3 protein)

Mus musculus

Mouse

SV-40 induced

 

NTC1_HUMAN (P46531)

Neurogenic locus notch homolog protein 1 [Precursor]

(NOTCH1)

Homo sapiens

Receptor for membrane-bound ligands; affects differentiation, proliferation and apoptosis

 

MET_HUMAN (P08581)

Hepatocyte growth factor receptor [Precursor]

(Met proto-oncogene; HGF receptor)

Homo sapiens

Receptor for hepatocyte growth factor; tyrosine protein kinase activity (EC 2.7.1.112)

 

IGFA_HUMAN (P01343)

Insulin-like growth factor IA [Precursor] (IGF-IA)

Homo sapiens

Growth-promoting activity

 

IGFB_HUMAN (P05019)

Insulin-like growth factor IB [Precursor] (IGF-IB)

Homo sapiens

Growth-promoting activity

 

TERT_HUMAN (O14746)

Telomerase reverse transcriptase

Homo sapiens

Elongates telomeres

(EC 2.7.7.-)

SV40-suppressed

RB_HUMAN (P06400)

Retinoblastoma-associated protein (RB)

Homo sapiens

Transcription co‑regulator, tumour suppressor; cell-cycle regulator

 

P53_HUMAN (P04637)

Cellular tumor antigen p53

Homo sapiens

Tumour suppressor, induces growth arrest or apoptosis; cell-cycle regulator

 

2AAA_HUMAN (P30153)

Serine/threonine protein phosphatase 2A, 65 KDa regulatory subunit A, alpha isoforms

(PP2A, subunit A, alpha isoforms)

Homo sapiens

Regulatory subunit of PP2A

 

Q9UND5

Ras association domain family 1 isoform A

(RASSF1A)

Homo sapiens

Tumour suppressor

 

RBL1_HUMAN (P28749)

P107

(Retinoblastoma-like protein 1)

Homo sapiens

Cell cycle regulation

 

RBL2_HUMAN (Q08999)

P130

(Retinoblastoma-like protein 2)

Homo sapiens

Cell cycle regulation

 

CBP_HUMAN (Q92793)

CREB-binding protein

(CBP)

Homo sapiens

Histone acetyltransferase (EC 2.3.1.48)

 

P300_HUMAN (Q09472)

P300 (E1A-associated protein p300)

Homo sapiens

Histone acetyltransferase

(EC 2.3.1.48)

Interact with SV40

TOP1_HUMAN (P11387)

DNA topoisomerase I

 

Homo sapiens

Converts DNA from one topological isomer to another

(EC 5.99.1.2)

 

RFA1_HUMAN (P27694)

Replication protein A 70 kDa DNA-binding subunit (RP-A)

Homo sapiens

Involved in initiation steps

 

RFA2_HUMAN (P15927)

Replication protein A 32 kDa subunit

(RP-A)

Homo sapiens

Involved in initiation steps

 

RFA3_HUMAN (P35244)

Replication protein A 14 kDa subunit

(RP-A)

Homo sapiens

Involved in initiation steps

 

RFA4_HUMAN (Q13156)

Replication protein A 30 kDa subunit

(RP-A)

Homo sapiens

Involved in initiation steps

 

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