SV40
This table contains entries for SV40 viral proteins in the UniProt databases, with links to view the original protein entries. There is also a list of some of the proteins known to interact with, be induced by or repressed by SV40 proteins.
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UniProt
|
Protein name |
Organism |
Function |
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Coat protein
VP1 |
Simian virus
40 (SV40) |
Forms part of viral capsid |
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|
Coat protein
VP2 (contains Coat protein VP3) |
Simian virus
40 (SV40) |
Forms part of viral capsid |
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|
|
Coat protein
VP3 |
Simian virus
40 (SV40) |
Forms part of viral capsid |
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|
|
DNA-binding
protein (Agnoprotein) |
Simian virus
40 (SV40) |
May have regulatory role in nucleic acid-protein
interactions |
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Large T
antigen |
Simian virus 40 (SV40) |
Initiates DNA unwinding and replication |
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|
|
Small T antigen |
Simian
virus 40 (SV40) |
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|
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|
Early leader protein (SELP) |
Simian virus
40 (SV40) |
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|
SV40-induced |
Neutrophil gelatinase-associated lipocalin [Precursor]
(SV-40 induced 24P3 protein) |
Mus musculus Mouse |
SV-40 induced |
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Neurogenic locus notch homolog protein 1 [Precursor] (NOTCH1) |
Homo sapiens |
Receptor
for membrane-bound ligands; affects differentiation, proliferation and apoptosis |
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Hepatocyte growth factor receptor [Precursor] (Met proto-oncogene; HGF receptor) |
Homo sapiens |
Receptor
for hepatocyte growth factor; tyrosine protein kinase activity (EC 2.7.1.112) |
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|
Insulin-like growth factor IA [Precursor] (IGF-IA) |
Homo sapiens |
Growth-promoting
activity |
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Insulin-like growth factor IB [Precursor] (IGF-IB) |
Homo sapiens |
Growth-promoting
activity |
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|
Telomerase
reverse transcriptase |
Homo sapiens |
Elongates telomeres |
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|
SV40-suppressed |
Retinoblastoma-associated protein (RB) |
Homo sapiens |
Transcription co‑regulator,
tumour suppressor; cell-cycle regulator
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Cellular tumor
antigen p53 |
Homo sapiens |
Tumour suppressor, induces growth arrest or apoptosis; cell-cycle regulator |
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Serine/threonine protein phosphatase 2A, 65 KDa regulatory subunit A, alpha isoforms (PP2A, subunit A, alpha isoforms) |
Homo sapiens |
Regulatory subunit of PP2A |
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|
|
Ras association domain family 1 isoform A (RASSF1A) |
Homo sapiens |
Tumour
suppressor |
|
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|
P107 (Retinoblastoma-like protein 1) |
Homo sapiens |
Cell cycle regulation |
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P130 (Retinoblastoma-like protein 2) |
Homo sapiens |
Cell cycle regulation |
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CREB-binding protein (CBP) |
Homo sapiens |
Histone acetyltransferase
(EC 2.3.1.48) |
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|
P300 (E1A-associated
protein p300) |
Homo sapiens |
Histone acetyltransferase |
|
|
Interact with SV40 |
DNA topoisomerase
I |
Homo sapiens |
Converts DNA from one topological
isomer to another
|
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Replication protein A 70 kDa DNA-binding subunit (RP-A) |
Homo sapiens |
Involved in initiation steps
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Replication protein A 32 kDa subunit (RP-A) |
Homo sapiens |
Involved in initiation steps |
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Replication protein A 14 kDa subunit (RP-A) |
Homo sapiens |
Involved in initiation steps |
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Replication protein A 30 kDa subunit (RP-A) |
Homo sapiens |
Involved in initiation steps |
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