Ubiquitin

This table contains entries for ubiquitin for a few representative organisms in the UniProt database, as well as for a few of the enzymes involved in ubiquitinylation. Links are provided to view the original UniProt protein entries, and their display in InterPro.

	SPTR	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match	Function
Ubiquitin IPR000626	UBIQ_HUMAN (P62988)	Ubiquitin	Homo sapiens			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
	UBIQ_CAEEL (P14792)	Ubiquitin	Caenorhabditis elegans Nematode worm			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
	UBIQ_SOYBN (P03993)	Ubiquitin	Glycine max Soybean			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
	UBIQ_ACECL (P42739)	Ubiquitin	Acetabularia cliftonii Green algae			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
	UBIQ_YEAST (P61864)	Ubiquitin	Saccharomyces cerevisiae Baker’s yeast			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
	UBIQ_TRYCR (P08565)	Ubiquitin	Trypanosoma cruzi Trypanosome			Involved in protein degradation, chromosome maintenance, gene expression regulation, stress response, ribosome biogenesis
Ubiquitin‑activating enzymes (E1)	UBA1_HUMAN (P22314)	Ubiquitin‑activating enzyme E1	Homo sapiens			Activates ubiquitin
IPR000011	UBA1_WHEAT (P20973)	Ubiquitin‑activating enzyme E1	Triticum aestivum Wheat			Activates ubiquitin
	UBA1_YEAST (P22515)	Ubiquitin‑activating enzyme E1	Saccharomyces cerevisiae Baker’s yeast			Activates ubiquitin
Ubiquitin‑conjugating enzymes (E2) IPR000608	UBCA_HUMAN (P49459)	Ubiquitin‑conjugating enzyme E2 A (EC 6.3.2.19)	Homo sapiens			Catalyses attachment of ubiquitin to proteins
	UBCC_HUMAN (O00762)	Ubiquitin‑conjugating enzyme E2 C (EC 6.3.2.19)	Homo sapiens			Catalyses attachment of ubiquitin to proteins
	UBCE_HUMAN (Q16763)	Ubiquitin‑conjugating enzyme E2 S (EC 6.3.2.19)	Homo sapiens			Catalyses attachment of ubiquitin to proteins
	UBC1_HUMAN (P61086)	Ubiquitin‑conjugating enzyme E2-25 kDa (EC 6.3.2.19)	Homo sapiens			Catalyses attachment of ubiquitin to proteins
Ubiquitin‑ligase (E3)	CBL_HUMAN (P22681) (RING-type)	CBL E3 ubiquitin protein ligase (EC 6.3.2.-)	Homo sapiens			Accepts ubiquitin from specific E2 proteins. Participates in signal transduction in hematopoietic cells
	MDM2_HUMAN (Q00987) (RING-type)	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-)	Homo sapiens			Accepts ubiquitin from specific E2 proteins. Acts on p53 tumour-suppressor.
	UE3A_HUMAN (Q05086) (HECT-type)	Ubiquitin‑conjugating enzyme E3A (EC 6.3.2.-)	Homo sapiens			Accepts ubiquitin from specific E2 proteins. Targets p53 tumour-suppressor protein for ubiquitin-mediated proteolysis
	HER3_HUMAN (Q15034) (HECT-type)	HECT domain and RCC1-like domain protein 3	Homo sapiens			Accepts ubiquitin from specific E2 proteins.
	RN37_HUMAN (O94941) (U-box-type)	RING finger protein 37	Homo sapiens			Accepts ubiquitin from specific E2 proteins. Interacts with UBE2L3
	FXLB_HUMAN (Q9Y2K7) (PHD-type)	F-box/LRR-repeat protein 11	Homo sapiens			Promotes ubiquitination and degradation of some phosphorylated proteins
Ubiquitin‑elongation enzymes (E4)	UB4A_HUMAN (Q14139)	Ubiquitin conjugation factor E4 A	Homo sapiens			Binds ubiquitin moieties and catalyses ubiquitin chain assembly
	UB4B_HUMAN (O95155)	Ubiquitin conjugation factor E4 B	Homo sapiens			Binds ubiquitin moieties and catalyses ubiquitin chain assembly