Serpins:
a1-antitrypsin
This table contains entries for a1-antitrypsin and related serpin family members for a few representative organisms from the UniProt database, with links to view the original protein entries.
|
|
UniProt entry
|
Protein name |
Organism |
Function |
|
a1-antitrypsin |
Alpha-1-antitrypsin |
Homo
sapiens |
Inhibits elastase |
|
|
|
Alpha-1-antiproteinase |
Bos Taurus Bovine |
Inhibits elastase |
|
|
|
Alpha-1-antiproteinase |
Rattus norvegicus Rat |
Inhibits elastase |
|
|
|
Alpha-1-antitrypsin
1-1 |
Mus musculus Mouse |
Inhibits elastase |
|
|
|
Alpha-1-antitrypsin
1-2 |
Mus musculus Mouse |
Inhibits elastase |
|
|
|
Alpha-1-antitrypsin
1-3 |
Mus musculus Mouse |
Inhibits elastase |
|
|
|
|
Alpha-1-antitrypsin
1-4 |
Mus musculus Mouse |
Inhibits elastase |
|
|
Alpha-1-antitrypsin
1-5 |
Mus musculus Mouse |
Inhibits elastase |
|
|
|
Alpha-1-antitrypsin
1-6 |
Mus musculus Mouse |
Inhibits elastase |
|
|
Other inhibitory serpins |
Alpha-1-antitrypsin-related
protein |
Homo
sapiens |
May be a pseudogene |
|
|
|
Alpha-2-antiplasmin |
Homo
sapiens |
Inhibits plasmin and trypsin |
|
|
|
Alpha-1-antichymotrypsin |
Homo
sapiens |
Inhibits neutrophils cathepsin G and mast
cell chymase |
|
|
|
Antithrombin-III |
Homo sapiens |
Regulates blood coagulation cascade |
|
|
|
Heparin cofactor II |
Homo
sapiens |
Regulates blood coagulation cascade |
|
|
|
Plasma protease
C1 inhibitor |
Homo sapiens |
Regulation of complement activation, blood coagulation,
fibrinolysis and the generation of kinins |
|
|
|
Plasma serine
protease inhibitor |
Homo sapiens |
Inhibits activated protein C and plasminogen activators |
|
|
|
Kallistatin |
Homo
sapiens |
Inhibits amidolytic and kininogenase activities of human
tissue kallikrein |
|
|
|
Neuroserpin |
Homo
sapiens |
Formation or reorganization of synaptic connections and
synaptic plasticity |
|
|
|
Plasminogen
activator inhibitor-1 |
Homo
sapiens |
Regulation of fibrinolysis |
|
|
|
Serpin I2 (Pancpin) |
Homo
sapiens |
Pancreatic tumour repressor |
|
|
|
Protein
Z-dependent protease inhibitor |
Homo
sapiens |
Inhibits factor Xa |
|
|
Iintracellular
serpins |
Leukocyte elastase inhibitor |
Homo sapiens |
Regulation of neutrophil proteases |
|
|
(ov-serpin
family) |
Maspin |
Homo sapiens |
Tumour suppressor, prevents metastasis |
|
|
|
Plasminogen
activator inhibitor-2 |
Homo
sapiens |
Tissue-type
plasminogen activator, intracellular signalling |
|
|
|
Placental thrombin inhibitor |
Homo
sapiens |
Inhibits thrombin |
|
|
|
Bomapin |
Homo
sapiens |
Haematopoiesis |
|
|
|
Serpin B11 |
Homo
sapiens |
|
|
|
|
Serpin B12 |
Homo sapiens |
Inhibits trypsin and plasmin |
|
|
|
Hurpin |
Homo sapiens |
Proliferation or differentiation of keratinocytes |
|
|
|
Squamous cell
carcinoma antigen 1 |
Homo sapiens |
Modulates immune response towards tumours |
|
|
|
Squamous cell
carcinoma antigen 2 |
Homo sapiens |
Modulates immune response towards tumours |
|
|
|
Megsin |
Homo sapiens |
Maturation of megakaryocytes |
|
|
|
Cytoplasmic antiproteinase 2 |
Homo
sapiens |
Furin |
|
|
|
Cytoplasmic antiproteinase 3 |
Homo
sapiens |
Granzyme B inhibitor |
|
|
Non-inhibitory
serpins |
Angiotensinogen |
Homo
sapiens |
Blood pressure regulation, hormone precursor |
|
|
|
Corticosteroid-binding globulin |
Homo
sapiens |
Hormone carrier (glucorticoids and progestins) |
|
|
|
Glia derived nexin |
Homo
sapiens |
Promotes neurite extension |
|
|
|
47 kDa heat shock protein |
Homo sapiens |
Molecular chaperone for collagen |
|
|
|
Pigment epithelium-derived factor |
Homo
sapiens |
Induces neuronal differentiation in retinoblastoma cells;
inhibitor of angiogenesis |
|
|
|
Collagen-binding
protein 2 |
Homo
sapiens |
Molecular chaperone for collagen |
|
|
|
Thyroxine-binding globulin |
Homo
sapiens |
Thyroid hormone transport |