Caspases
This table contains entries for human caspases in the UniProt database, as well as for a few of the proteins that interact with caspases. Links are provided to view the original protein entries.
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SPTR
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Protein name |
Organism |
ENZYME; MEROPS |
InterPro Domain Architecture |
InterPro Graphical Match |
Function |
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Caspases |
Interleukin-1
beta convertase precursor (caspase-1) |
Homo sapiens
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MEROPS family C14
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Thiol protease that cleaves IL-1 beta, releasing mature
cytokine that is involved in inflammatory processes. Not involved in
apoptosis. |
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Caspase-2 |
Homo sapiens |
MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. |
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Apopain
(caspase-3) |
Homo sapiens |
MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. Cleaves PARP, SREBPs, huntingtin and caspases-6, -7
and –9. |
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Caspase-4 |
Homo sapiens |
MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. Cleaves caspase-1. |
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Caspase-5 |
Homo sapiens
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MEROPS family C14 |
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Mediator of programmed cell death. |
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Caspase-6 |
Homo sapiens
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MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. Cleaves laminins and PARP in vitro. |
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Caspase-7 |
Homo sapiens
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MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. Cleaves PARP and SREBPs. |
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Caspase-8 |
Homo sapiens
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MEROPS family C14 |
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Most upstream protease of the activation cascade of
caspases responsible for apoptosis execution. |
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Caspase-9 |
Homo sapiens
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MEROPS family C14 |
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Involved in the activation cascade of caspases responsible
for apoptosis execution. Activates Apaf-1, which activates caspase-3. Cleaves
PARP. |
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Caspase-10 |
Homo sapiens
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MEROPS family C14 |
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Involved in the activation cascade of caspases responsible for apoptosis execution. May participate in the granzyme B apoptotic pathways. Cleaves caspases-3, -4, -6, -7, -8, and -9. |
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Caspase-14 |
Homo sapiens
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MEROPS family C14 |
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May be involved in the death receptor and granzyme B apoptotic pathways. May function as a downstream signal transducer of cell death. |
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Other
Apoptosis Proteins – Extrinsic Pathway |
Tumor necrosis
factor precursor (TNFa) |
Homo sapiens |
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Cytokine that binds to TNFR1 and TNFBR. Mainly secreted by macrophages and can induce cell death of certain tumour cell lines. |
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Lymphotoxin-a |
Homo sapiens |
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Cytokine that in its homotrimeric form binds to TNFR1,
TNFBR and TNFRSF14. In its heterotrimeric form with LTB binds to TNFRSF3. |
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Tumor necrosis factor ligand superfamily member 6 (FasL) |
Homo sapiens |
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Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. |
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TNFRSF1 (TNF receptor superfamily 1A) |
Homo sapiens |
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Receptor for TNFa and lymphotoxin-a. The adaptor molecule FADD recruits caspase-8 to the activated receptor. |
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TNFRSF6 (TNF receptor superfamily 6) |
Homo sapiens |
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Receptor for TNFSF6/FASL. The adapter molecule FADD recruits caspase-8 to the activated receptor. |
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FADD protein |
Homo sapiens |
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Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas or TNFR-1 receptors. |
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TRADD protein |
Homo sapiens |
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Adapter molecule for TNFR1 that associates with the
cytoplasmic domain of TNFR1 mediating its interaction with FADD. |
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Other Apoptosis Proteins – Intrinsic Pathway |
Cellular tumor
antigen p53 |
Homo sapiens |
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Acts as a tumour suppressor in many tumour types; induces
growth arrest or apoptosis depending on the physiological circumstances and
cell type. |
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Apoptosis
regulator Bcl-2 |
Homo sapiens
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Suppresses apoptosis in a variety of cell systems. Regulates cell death by controlling the mitochondrial membrane permeability. |
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Apoptosis
regulator Bcl-X |
Homo sapiens
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The Bcl-X(L) isoform is a potent inhibitor of apoptosis, while the Bcl-X(S) isoform promotes apoptosis. |
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Cytochrome C |
Homo sapiens |
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Electron carrier protein. |
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Apoptotic protease activating factor 1 |
Homo sapiens |
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Mediates cytochrome c-dependent autocatalytic activation of pro-caspase-9, leading to the activation of caspase-3 and apoptosis. |
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NACHT-, LRR- and PYD-containing protein 2 |
Homo sapiens
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Form cytoplasmic death effector filaments. Enhances APAF1
and cytochrome c-dependent activation of pro-caspase-9. |
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Cell
Destruction Proteins |
DNA fragmentation factor alpha subunit (ICAD) |
Homo sapiens
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Inhibitor of the caspase-activated DNase (DFF40). |
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DNA
fragmentation factor 40 kDa subunit (CAD) |
Homo sapiens
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Nuclease that induces DNA fragmentation and chromatin
condensation during apoptosis. |
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Caspase Inhibitors |
CASP8 and FADD-like apoptosis regulator precursor |
Homo sapiens
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MEROPS family C14 |
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Apoptosis regulator protein. Inhibitor of TNFRSF6-mediated
apoptosis. Lacks enzymatic (caspase) activity. |
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Caspase-1 inhibitor Iceberg |
Homo sapiens
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Inhibits generation of IL-1beta by interacting with
caspase-1 and preventing its association with RIP2. |
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Baculoviral IAP repeat-containing protein 1 |
Homo sapiens |
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Prevents motor-neuron apoptosis induced by a variety of
signals. |
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Serine proteinase inhibitor 2 (Serpin 2) |
Homo sapiens
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Inhibitor of caspase‑1, suppressing an interleukin-1
beta response to infection. Also inhibits granzyme B. |
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