Cholera Toxin

This table contains entries for a variety of cholera toxins in the UniProt database. Links are provided to view the original UniProt protein entries, and their display in InterPro.

		SPTR	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match	Function
Cholera toxins	CT-A	CHTA_VIBCH (P01555)	Cholera enterotoxin, A chain precursor (NAD(+)‑diphthamide ADP‑ribosyltransferase) (EC 2.4.2.36)	Vibrio cholerae			Catalyses ADP-ribosylation of Gsa to activate the adenylate cyclase
	CT-B	CHTB_VIBCH (P01556)	Cholera enterotoxin subunit B precursor	Vibrio cholerae			Directs A subunit to its target by binding GM1 gangliosides on surface of intestinal epithelial cells
	ZOT	ZOT_VIBCH (P38442)	Zona occludens toxin	Vibrio cholerae			Increases permeability of small intestine mucosa by affecting structure of intercellular tight junctions (zonula occludens)
	ACE	ACE_VIBCH (P38441)	Accessory cholera enterotoxin	Vibrio cholerae	Not represented	Not represented	Increase fluid secretion
		ALDH_VIBCH (P23240)	Aldehyde dehydrogenase (EC 1.2.1.3)	Vibrio cholerae			May be involved in V. cholerae virulence, as its expression is under the control of toxR
	epsD	GSPD_VIBCH (P45779)	Cholera toxin secretion protein epsD	Vibrio cholerae			Required for secretion of cholera toxin through outer membrane
	ST	HSTN_VIBCH (P0A4M3)	NAG-specific heat-labile toxin ST precursor	Vibrio cholerae			Toxin
	STO	HSTO_VIBCH (Q07425)	Heat-stable enterotoxin STO precursor	Vibrio cholerae			Toxin
	Haemolysin	HLYA_VIBCH (P09545)	Haemolysin precursor	Vibrio cholerae			Exotoxins that attack blood cell membranes and cause cell rupture
	Pilus	TCPA1_VIBCH (Q60153)	Toxin coregulated pilin precursor	Vibrio cholerae			Constituent of pili; may be involved in adhesion of V. cholerae to host intestinal epithelium
	Pilus	TCPA2_VIBCH (P23024)	Toxin coregulated pilin precursor	Vibrio cholerae			Constituent of pili; may be involved in adhesion of V. cholerae to host intestinal epithelium
	Membrane protein	OMPU_VIBCH (P97085)	Outer membrane porin protein U precursor	Vibrio cholerae			Integral membrane protein
	Memebrane protein	O86021_VIBCH (O86021)	Outer membrane protein T precursor	Vibrio cholerae	Not represented		Integral membrane protein
	ToxR	TOXR_VIBCH (P15795)	Cholera toxin transcriptional activator	Vibrio cholerae			Transcription activator controling cholera toxin, pilus colonization factor and outer membrane protein expression in V. cholerae
	ToxT	Q9F5R1_VIBCH (Q9F5R1)	Toxin co-regulated pilus virulence regulatory protein ToxT	Vibrio cholerae			Transcription factor
	TcpP	TCPP_VIBCH (P29485)	Toxin coregulated pilus biosynthesis protein P	Vibrio cholerae			Involved in TCP pilus biogenesis

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