DNA Topoisomerase

This table contains entries for different DNA topoisomerases from a variety of species in the UniProt database. Links are provided to view the original UniProt protein entries, and their display in InterPro.

	SPTR	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match
Class I Topoisomerases	TOP1_HUMAN (P11387)	DNA topoisomerase I (EC 5.99.1.2)	Homo sapiens
	TOP1M_HUMAN (Q969P6)	DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)	Homo sapiens
	TOP1_YEAST (P04786)	DNA topoisomerase I (EC 5.99.1.2)	Saccharomyces cerevisiae Yeast
	TOP1_METJA (Q59046)	DNA topoisomerase I (EC 5.99.1.2)	Methanococcus jannaschii Archaea
	TOP1_ECOLI (P06612)	DNA topoisomerase I (EC 5.99.1.2)	Escherichia coli Proteobacteria
	TOP1_VACCA (Q76ZS7)	DNA topoisomerase I (EC 5.99.1.2)	Vaccinia virus
	TOP3A_HUMAN (Q13472)	DNA topoisomerase III alpha, (EC 5.99.1.2)	Homo sapiens
	TOP3B_HUMAN (O95985)	DNA topoisomerase III beta‑1, (EC 5.99.1.2)	Homo sapiens
	TOP3_YEAST (P13099)	DNA topoisomerase III, (EC 5.99.1.2)	Saccharomyces cerevisiae Yeast
	TOP3_ECOLI (P14294)	DNA topoisomerase III, (EC 5.99.1.2)	Escherichia coli Proteobacteria
Class II Topoisomerases	TOP2A_HUMAN (P11388)	DNA topoisomerase 2-alpha, (EC 5.99.1.3)	Homo sapiens
	TOP2B_HUMAN (Q02880)	DNA topoisomerase 2‑beta, (EC 5.99.1.3)	Homo sapiens
	TOP2_YEAST (P06786)	DNA topoisomerase 2, (EC 5.99.1.3)	Saccharomyces cerevisiae Yeast
	GYRA_HALSQ (P21557)	DNA gyrase subunit A, (EC 5.99.1.3)	Haloferax sp. Archaea
	GYRB_HALSQ (P21558)	DNA gyrase subunit B, (EC 5.99.1.3)	Haloferax sp. Archaea
	GYRA_ECOLI (P0AES4)	DNA gyrase subunit A, (EC 5.99.1.3)	Escherichia coli Proteobacteria
	GYRB_ECOLI (P0AES6)	DNA gyrase subunit B, (EC 5.99.1.3)	Escherichia coli Proteobacteria
	TOP2_ASFM2 (P34203)	DNA topoisomerase 2, (EC 5.99.1.3)	African Swine fever virus
	TOP6A_AERPE (Q9YE67)	DNA topoisomerase VI subunit A, (EC 5.99.1.3)	Aeropyrum pernix Archaea
	TOP6B_AERPE (Q9YE64)	DNA topoisomerase VI subunit B, (EC 5.99.1.3)	Aeropyrum pernix Archaea