Tissue Factor

This table contains entries for Tissue Factor proteins from different species in the UniProt database, as well as other blood coagulation proteins and inhibitors. Links are provided to view the original UniProt protein entries, and their display in InterPro.

		UniProt	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match	Function
Tissue Factor		TF_HUMAN (P13726)	Tissue factor precursor	Homo sapiens			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
		TF_RAT (P42533)	Tissue factor precursor	Rattus norvegicus Rat			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
		TF_MOUSE (P20352)	Tissue factor precursor	Mus musculus Mouse			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
		TF_BOVIN (P30931)	Tissue factor precursor	Bos Taurus Bovine			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
		TF_CAVPO (Q9JLU8)	Tissue factor precursor	Cavia porcellus Guinea pig			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
		TF_RABIT (P24055)	Tissue factor precursor	Oryctolagus cunuculus Rabbit			Initiates blood coagulation by forming complex with circulating FVII or FVIIa
Coagulation Pathway Proteins	FII (thrombin)	THRB_HUMAN (P00734)	Prothrombin precursor (EC 3.4.21.5)	Homo sapiens			Converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
		THRB_MOUSE (P19221)	Prothrombin precursor (EC 3.4.21.5)	Mus musculus Mouse			Converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
	FV	FA5_HUMAN (P12259)	Coagulation factor V precursor	Homo sapiens			Acts as a cofactor for FXa to activate prothrombin to thrombin.
		FA5_BOVIN (Q28107)	Coagulation factor V precursor	Bos Taurus Bovine			Acts as a cofactor for FXa to activate prothrombin to thrombin.
	FVII	FA7_HUMAN (P08709)	Coagulation factor VII precursor (EC 3.4.21.21)	Homo sapiens			Initiates the extrinsic pathway of blood coagulation.
		FA7_MOUSE (P70375)	Coagulation factor VII precursor (EC 3.4.21.21)	Mus musculus Mouse			Initiates the extrinsic pathway of blood coagulation.
	FVIII	FA8_HUMAN (P00451)	Coagulation factor VIII precursor	Homo sapiens			Acts as a cofactor for FIXa to convert FX to FXa.
		FA8_MOUSE (Q06194)	Coagulation factor VIII precursor	Mus musculus Mouse			Acts as a cofactor for FIXa to convert FX to FXa.
	FIX	FA9_HUMAN (P00740)	Coagulation factor IX precursor (EC 3.4.21.22)	Homo sapiens			Converts FX to FXa in the presence of calcium, phospholipids, and FVIIIa.
		FA9_MOUSE (P16294)	Coagulation factor IX precursor (EC 3.4.21.22)	Mus musculus Mouse			Converts FX to FXa in the presence of calcium, phospholipids, and FVIIIa.
	FX	FA10_HUMAN (P00742)	Coagulation factor X precursor (EC 3.4.21.6)	Homo sapiens			Converts prothrombin to thrombin in the presence of FVa, calcium and phospholipids.
		FA10_MOUSE (O88947)	Coagulation factor X precursor (EC 3.4.21.6)	Mus musculus Mouse			Converts prothrombin to thrombin in the presence of FVa, calcium and phospholipids.
	FXI	FA11_HUMAN (P03951)	Coagulation factor XI precursor (EC 3.4.21.27)	Homo sapiens			Converts FIX to active FIXa.
		FA11_MOUSE (Q91Y47)	Coagulation factor XI precursor (EC 3.4.21.27)	Mus musculus Mouse			Converts FIX to active FIXa.
	FXIII A-chain	F13A_HUMAN (P00488)	Coagulation factor XIII A chain precursor (EC 2.3.2.13)	Homo sapiens			Activated by thrombin to a transglutaminase that catalyzes the formation of g‑glutamyl-e-lysine cross-links between fibrin chains, to stabilize fibrin clots.
		F13A_MOUSE (Q8BH61)	Coagulation factor XIII A chain precursor (EC 2.3.2.13)	Mus musculus Mouse			Activated by thrombin to a transglutaminase that catalyzes the formation of g‑glutamyl-e-lysine cross-links between fibrin chains, to stabilize fibrin clots.
	FXIII B-chain	F13B_HUMAN (P05160)	Coagulation factor XIII B chain precursor	Homo sapiens			FXIII B chain is not catalytically active, but may stabilize A subunits and regulate rate of transglutaminase formation by thrombin
		F13B_MOUSE (Q07968)	Coagulation factor XIII B chain precursor	Mus musculus Mouse			FXIII B chain is not catalytically active, but may stabilize A subunits and regulate rate of transglutaminase formation by thrombin
	Fibrin a‑chain	FIBA_HUMAN (P02671)	Fibrinogen alpha chain precursor	Homo sapiens			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
		FIBA_RAT (P06399)	Fibrinogen alpha chain precursor	Rattus norvegicus Rat			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
	Fibrin b‑chain	FIBB_HUMAN (P02675)	Fibrinogen beta chain precursor	Homo sapiens			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
		FIBB_RAT (P14480)	Fibrinogen beta chain precursor	Rattus norvegicus Rat			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
	Fibrin g‑chain	FIBG_HUMAN (P02679)	Fibrinogen gamma chain precursor	Homo sapiens			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
		FIBG_RAT (P02680)	Fibrinogen gamma chain precursor	Rattus norvegicus Rat			Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Heterohexamer a2b2g2
Coagulation Pathway Inhibitors		TFPI1_HUMAN (P10646)	Tissue factor pathway inhibitor precursor	Homo sapiens			Inhibits FX and FXa, inhibits TF/FVIIa activity; may form TF/FVIIa/FXa/TFPI complex.
		TFPI2_HUMAN (P48307)	Tissue factor pathway inhibitor 2 precursor	Homo sapiens			Seems to inhibit trypsin, TF/FVIIa, and weakly FXa.
		TFPI1_MACMU (Q28864)	Tissue factor pathway inhibitor precursor	Macaca mulatto Rhesus macaque			Inhibits FX and FXa, inhibits TF/FVIIa activity; may form TF/FVIIa/FXa/TFPI complex.
		TFPI1_RAT (Q02445)	Tissue factor pathway inhibitor precursor	Rattus norvegicus Rat			Inhibits FX and FXa, inhibits TF/FVIIa activity; may form TF/FVIIa/FXa/TFPI complex.
		TFPI1_MOUSE (O54819)	Tissue factor pathway inhibitor precursor	Mus musculus Mouse			Inhibits FX and FXa, inhibits TF/FVIIa activity; may form TF/FVIIa/FXa/TFPI complex.
		TFPI2_MOUSE (O35536)	Tissue factor pathway inhibitor 2 precursor	Mus musculus Mouse			Seems to inhibit trypsin, TF/FVIIa, and weakly FXa.
		TFPI1_RABIT (P19761)	Tissue factor pathway inhibitor precursor	Oryctolagus cunuculus Rabbit			Inhibits FX and FXa, inhibits TF/FVIIa activity; may form TF/FVIIa/FXa/TFPI complex.