RNA Exosomes

 

This table contains entries for RNA exosomes from different species in the UniProt database.  Links are provided to view the original UniProt protein entries and their display in InterPro. 

 

 

UniProt

Protein name

Organism

InterPro Domain

Architecture

InterPro

Graphical

Match

Function

Exosome PH‑ring subunits

RRP41_YEAST (P46948)

Exosome exonuclease RRP41

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

 

EXOS4_HUMAN (Q9NPD3)

Exosome complex exonuclease RRP41

(EC 3.1.13.-)

Homo sapiens

Participate in 3'-5' exonuclease activity

 

RRP42_YEAST (Q12277)

Exosome exonuclease RRP42

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

 

EXOS7_HUMAN (Q15024)

Exosome complex exonuclease RRP42

(EC 3.1.13.-)

Homo sapiens

Participate in 3'-5' exonuclease activity

 

RRP43_YEAST (P25359)

Exosome exonuclease RRP43

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

 

EXOS8_HUMAN (Q96B26)

Exosome complex exonuclease RRP43

(EC 3.1.13.-)

Homo sapiens

Participate in 3'-5' exonuclease activity

 

RRP45_YEAST (Q05636)

Exosome exonuclease RRP45

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

 

EXOS9_HUMAN (Q06265)

Exosome complex exonuclease RRP45

(EC 3.1.13.-)

Homo sapiens

Participate in 3'-5' exonuclease activity

 

RRP46_YEAST (P53256)

Exosome exonuclease RRP46

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

 

EXOS5_HUMAN (Q9NQT4)

Exosome complex exonuclease RRP46

(EC 3.1.13.-)

Homo sapiens

Participate in 3'-5' exonuclease activity

 

MTR3_YEAST (P48240)

Exosome complex exonuclease MTR3

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

Participate in 3'-5' exonuclease activity

Exosome cap subunits

CSL4_YEAST (P53859)

3'-5' exoribonuclease CSL4

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

None

RNA/protein binding

 

EXOS1_HUMAN (Q9Y3B2)

3'-5' exoribonuclease CSL4 homolog

(EC 3.1.13.-)

Homo sapiens

RNA/protein binding

 

RRP4_YEAST (P38792)

Exosome exonuclease RRP4

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

RNA/protein binding

 

EXOS2_HUMAN (Q13868)

Exosome complex exonuclease RRP4

(EC 3.1.13.-)

Homo sapiens

RNA/protein binding

 

RRP40_YEAST (Q08285)

Exosome exonuclease RRP40

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

RNA/protein binding

 

EXOS3_HUMAN (Q9NQT5)

Exosome complex exonuclease RRP40

(EC 3.1.13.-)

Homo sapiens

None

RNA/protein binding

Accessory proteins

RRP6_YEAST (Q12149)

Exosome exonuclease 6

EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

3'-5' exonuclease activity

 

EXOSX_HUMAN (Q01780)

Exosome component 10

Homo sapiens

3'-5' exonuclease activity

 

RRP44_YEAST (Q08162)

Exosome exonuclease RRP44

(EC 3.1.13.-)

Saccharomyces cerevisiae

Baker’s yeast

3'-5' exonuclease activity; associated with the GTPase Ran

 

RRP44_HUMAN (Q9Y2L1)

Exosome complex exonuclease RRP44

(EC 3.1.13.-)

Homo sapiens

3'-5' exonuclease activity; associated with the GTPase Ran

 

DCP1_YEAST (Q12517)

mRNA decapping enzyme subunit 1

Saccharomyces cerevisiae

Baker’s yeast

Component of the decapping complex for degradation of mRNAs

 

DCPS_HUMAN (Q96C86)

mRNA decapping enzyme DcpS

(EC 3.-.-.-)

Homo sapiens

Removes 7-methyl guanine cap structure from mRNA fragments

PNPases

PNP_ECOLI (P05055)

Polyribonucleotide nucleotidyltransferase

(EC 2.7.7.8)

Escherichia coli

Bacteria

mRNA degradation

 

PNPT1_MOUSE (Q8K1R3)

Polyribonucleotide nucleotidyltransferase (mitochrondria)

(EC 2.7.7.8)

Mus musculus

Mouse (mitochondria)

mRNA degradation

TRAMP complex

AIR1_YEAST (P40507)

Protein AIR1 (Arg methyltransferase-interacting RING finger protein 1)

Saccharomyces cerevisiae

Baker’s yeast

Stimulates exosome degradation

 

AIR2_YEAST (Q12476)

Protein AIR2 (Arg methyltransferase-interacting RING finger protein 2)

Saccharomyces cerevisiae

Baker’s yeast

Stimulates exosome degradation

 

HUL4_YEAST (P40985)

Ubiquitin‑protein ligase HUL4

(HECT ubiquitin ligase 4)

(EC 6.3.2.-)

Saccharomyces cerevisiae

Baker’s yeast

Stimulates exosome degradation

 

MTR4_YEAST (P47047)

ATP-dependent RNA helicase DOB1

(EC 3.6.1.-)

Saccharomyces cerevisiae

Baker’s yeast

Unwinds secondary structure in pre-rRNA

 

PAP2_YEAST (P53632)

Poly(A) RNA polymerase protein 2

(EC 2.7.7.-)

Saccharomyces cerevisiae

Baker’s yeast

Catalytic subunit with polyadenylation activity

 

TRF5_YEAST (P48561)

Poly(A) RNA polymerase protein 1

(EC 2.7.7.-)

Saccharomyces cerevisiae

Baker’s yeast

Catalytic subunit with polyadenylation activity

SKI complex

SKI2_YEAST (P35207)

Antiviral helicase SKI2

(Superkiller protein 2)

(EC 3.6.1.-)

Saccharomyces cerevisiae

Baker’s yeast

RNA helicase involved in 3'-mRNA degradation

 

SKI3_YEAST (P17883)

Superkiller protein 3

Saccharomyces cerevisiae

Baker’s yeast

Involved in 3'-mRNA degradation

 

SKI7_YEAST (Q08491)

Superkiller protein 7

Saccharomyces cerevisiae

Baker’s yeast

Mediates interactions between exosome and SKI complex

 

SKI8_YEAST (Q02793)

Antiviral protein SKI8

(Superkiller protein 8)

Saccharomyces cerevisiae

Baker’s yeast

Involved in 3'-mRNA degradation

 

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