DNA Ligase IV
This table contains entries for DNA ligase IV and other members of the DNA ligase family, as well as for different proteins involved in non-homologous end joining DNA repair, for a few representative organisms from the UniProt/Swiss-Prot & TrEMBL database, with links to view the original protein entries. Links are included to the graphical matches in InterPro for each protein, which displays the signatures that match the protein, the structural information for the protein, as well as its domain architecture.
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UniProt/Swiss-Prot & TrEMBL
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Protein name |
InterPro graphical match |
Organism |
Function |
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DNA ligases |
DNA ligase IV |
DNA ligase IV |
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Homo
sapiens |
Interacts with XRCC4; joins single strand breaks in
double-stranded DNA |
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DNA ligase IV
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Mus
musculus Mouse |
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Other
ATP-dependent DNA ligases |
DNA ligase I
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Homo
sapiens |
Seals nicks in double-stranded DNA (during replication,
recombination, repair) |
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DNA ligase I
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Mus
musculus Mouse |
Seals nicks in double-stranded DNA (during replication,
recombination, repair) |
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DNA ligase III
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Homo
sapiens |
Interacts with XRCC1; corrects defective DNA strand-break
repair and sister chromatid exchange |
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DNA ligase III
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Mus
musculus Mouse |
Interacts with XRCC1; corrects defective DNA strand-break
repair and sister chromatid exchange |
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DNA ligase I, mitochondrial precursor |
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Saccharomyces
cerevisiae Yeast |
Seals
nicks in double-stranded DNA (during replication, recombination, repair). The
mitochondrial form is required for mitochondrial DNA maintenance but is
non-essential |
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DNA ligase |
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Aeropyrum pernix
Archaea |
Seals nicks in double-stranded DNA (during replication,
recombination, repair) |
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DNA ligase |
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Haemophilus influenzae Bacteria |
Catalyzes
efficient strand joining on a single nicked DNA |
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DNA ligase |
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Fowlpox
virus dsDNA virus |
Seals nicks in double-stranded DNA (during replication,
recombination, repair) |
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NAD-dependent DNA
ligases |
DNA ligase |
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Haemophilus influenzae Bacteria |
Catalyzes
the formation of phosphodiester linkages between 5'-phosphoryl and
3'-hydroxyl groups in ds DNA; requires NAD |
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DNA ligase |
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Bacillus stearothermophilus Bacteria |
Catalyzes
the formation of phosphodiester linkages between 5'-phosphoryl and
3'-hydroxyl groups in ds DNA; requires NAD |
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Other NHEJ
proteins |
Ku |
ATP-dependent
DNA helicase II, 70 kDa subunit (Ku70) |
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Homo
sapiens |
Single-stranded DNA-dependent ATP-dependent helicase |
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ATP-dependent
DNA helicase II, 70 kDa subunit (Ku70) |
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Mus
musculus Mouse |
Single-stranded DNA-dependent ATP-dependent helicase |
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ATP-dependent DNA helicase II, 80 kDa subunit (Ku80; Ku86) |
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Homo
sapiens |
Single-stranded
DNA-dependent ATP-dependent helicase |
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ATP-dependent DNA helicase II, 80 kDa subunit (Ku80; Ku86) |
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Mus
musculus Mouse |
Single-stranded
DNA-dependent ATP-dependent helicase |
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DNA-PKcs |
DNA-dependent protein kinase catalytic subunit |
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Homo
sapiens |
Ser/Thr kinase that must be bound to DNA to express its
catalytic qualities |
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DNA-dependent protein kinase catalytic subunit |
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Mus
musculus Mouse |
Ser/Thr kinase that must be bound to DNA to express its
catalytic qualities |
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XRCC4 |
DNA-repair protein XRCC4 |
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Homo
sapiens |
Binds to
DNA and to DNA ligase IV, where the XRCC4/ligase complex is responsible for
the NHEJ ligation step; XRCC4 enhances the joining activity of DNA ligase IV |
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DNA-repair
protein XRCC4 |
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Mus
musculus Mouse |
Binds to
DNA and to DNA ligase IV, where the XRCC4/ligase complex is responsible for
the NHEJ ligation step, and XRCC4 enhances the joining activity of DNA ligase
IV |
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Artemis |
Artemis protein |
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Homo sapiens |
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Similar to ARTEMIS protein |
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Mus
musculus Mouse |
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