Catalase

P04040 Human Catalase Entry from InterPro

InterPro Domain architecture

InterPro Entry	Method accession	Graphical match	Method name
IPR002226	PD000510		Catalase
IPR002226	PF00199		Catalase
IPR002226	PR00067		CATALASE
IPR002226	PS00437		CATALASE_1
IPR002226	PS00438		CATALASE_2
IPR002226	SSF56634		Catalase
Classification	PBD Chain/Domain ID	PDB Chain/Structural Domains
1f4j	1f4ja
1f4j	1f4jb
1f4j	1f4jc
1f4j	1f4jd
2.40.180.10.1	1qqwA0
e.5.1.1	d1dgfa_

What InterPro Tells Us

From the graphical match table above, you can see that all six signatures (method accession) are found in one InterPro entry, IPR002226, representing the catalase family of proteins. These signatures are: PD000510 from the PRODOM database, PF00199 from the PFAM database, PR00067 from the PRINTS database, PS00437 and PS00438 from the PROSITE database, and SSF56634 from the SUPERFAMILY database. The PROSITE signatures represent small conserved regions in the catalase family, including the sequences around a tyrosine haem proximal side ligand and a haem-binding arginine residue for PS00437, and the sequences around a conserved histidine involved in catalysis for PS00438. The PRINTS signature is derived from seven conserved elements within the catalase family. The PFAM signature represents the conserved core of the catalase family, while the PRODOM and SUPERFAMILY signatures are closer to the full-length of the proteins.

The remaining entries in the table are from the structural database PDB (green stripe), and from the structural classification databases CATH (pink stripe) and SCOP (black stripe) (the names such as 1qqwA0 are derived from the PDB entry upon which they are based, here PDB entry 1qqw, chain a). The graphical match for the PDB entry 1f4j displays the length of the original PDB entry. There are four identical chains in the PDB entry (1f4ja, 1f4jb, 1f4jc, and 1f4jd) representing the tetrameric structure of human catalase. Both the CATH (1qqwA0) and the SCOP (d1dgfa_) databases describe the structural features and classification of the human catalase protein structure. These last six entries are not signatures, but are direct structural links.

What the Structure Tells Us

Structures associated with human catalase (P04040) can be viewed using AstexViewer®, which is linked from the Match Table diagrammed above via the logo on the InterPro page (please note, there is no link directly from this page, therefore you need to go to the link on the InterPro page for this protein). The AstexViewer® displays the PDB structure with the CATH or SCOP domain highlighted (therefore each link highlights a different region).

There are structures available for catalases from several different organisms, including human, bovine, yeast, and Escherichia coli, amongst others, in the Protein Data Bank (PDB). A detailed description and visualisation of the structural features of catalases can be found at the PBD ‘Molecule of the Month’. The crystallographic structures of different catalases have provided insight into the catalytic action of these enzymes.

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