TRK
Receptors
This table contains entries for TRK receptors and their neurotrophin ligands for a variety of species in the UniProt database. Links are provided to view the original UniProt protein entries, and their display in InterPro.
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SPTR
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Protein name |
Organism |
InterPro Domain Architecture |
InterPro Graphical Match |
Function |
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Trk Receptors |
TrkA |
High affinity nerve growth factor receptor precursor |
Homo sapiens
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Crucial role in development and function of nociceptive reception
system, and thermal regulation |
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High affinity nerve growth factor receptor precursor |
Rattus norvegicus
Rat |
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Crucial role in development and function of nociceptive
reception system, and thermal regulation |
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High affinity nerve growth factor receptor precursor |
Gallus gallus
Chicken |
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High
affinity binding to nerve growth factor |
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TrkB |
BDNF/NT-3 growth factors receptor precursor |
Homo sapiens
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Involved in the development and/or maintenance of the
nervous system. |
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BDNF/NT-3 growth factors receptor precursor |
Mus musculus
Mouse |
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Involved in the development and/or maintenance of the
nervous system. |
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BDNF/NT-3 growth factors receptor precursor |
Rattus norvegicus
Rat |
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Involved in the development and/or maintenance of the
nervous system. |
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BDNF/NT-3 growth factors receptor precursor |
Gallus gallus
Chicken |
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Involved in the development and/or maintenance of the
nervous system. |
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TrkC |
NT-3 growth factor receptor precursor |
Homo sapiens
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Tyrosine-protein kinase receptor |
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NT-3 growth factor receptor precursor |
Rattus norvegicus
Rat |
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Tyrosine-protein kinase receptor |
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NT-3 growth factor receptor precursor |
Gallus gallus
Chicken |
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Tyrosine-protein kinase receptor |
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NT-3 growth factor receptor precursor |
Pan troglodytesChimpanzee |
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Tyrosine-protein
kinase receptor |
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NT-3 growth factor receptor precursor |
Macaca fascicularis
Crab‑eating macaque |
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Tyrosine-protein kinase receptor |
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NT-3 growth factor receptor precursor |
Sus scrofa
Pig |
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Tyrosine-protein kinase receptor |
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Neurotrophins |
NGF |
Neurotrophin-5
precursor (Nerve
growth factor) |
Homo sapiens
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Specific for TrkA receptors |
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Neurotrophin-5
precursor (Nerve
growth factor) |
Rattus norvegicus
Rat |
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Specific for TrkA receptors |
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Neurotrophin-5
precursor (Nerve
growth factor) |
Mus musculus
Mouse |
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Specific for TrkA receptors |
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BDNF |
Brain‑derived neurotrophic factor precursor |
Homo sapiens
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Specific for TrkB receptors |
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Brain-derived neurotrophic factor precursor |
Mus musculus
Mouse |
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Specific for TrkB receptors |
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Brain-derived neurotrophic factor precursor |
Rattus norvegicus
Rat |
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Specific for TrkB receptors |
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NT3 |
Neurotrophin-3
precursor |
Homo sapiens
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Greatest affinity for TrkC |
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Neurotrophin-3
precursor |
Mus musculus
Mouse |
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Greatest affinity for TrkC |
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Neurotrophin-3
precursor |
Rattus norvegicus
Rat |
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Greatest affinity for TrkC |
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Neurotrophin-3 precursor |
Gallus gallus
Chicken |
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Greatest affinity for TrkC |
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NT4 |
Neurotrophin-4
precursor |
Xenopus laevis
Frog |
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Specific for TrkB receptors |
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Neurotrophin-4
precursor |
Vipera lebetina
Elephant snake |
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Specific for TrkB receptors |
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NT7 |
Neurotrophin-7
precursor |
Brachydanio rerio
Zebrafish |
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May have similar receptor specificity as NGF |
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Neurotrophin-7
precursor |
Cyprinus carpio
Common carp |
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May have similar receptor specificity as NGF |
