Cytochrome P450
This table contains entries for CYP proteins from humans in the UniProt database. Links are provided to view the original UniProtKB protein entries and their display in InterPro. There are also about 15 CYP pseudogenes in humans, which have been excluded from the table below.
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UniProt
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Protein name |
Organism |
InterPro Domain Architecture
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InterPro Graphical Match |
Function |
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Cytochrome P450 |
Cytochrome P450 1A1 (CYP1A1) |
Homo sapiens
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Degrade xenobiotics, steroids
and fatty acids. Expressed in lung, lymphocytes, placenta |
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Cytochrome P450 1A2 (CYP1A2) |
Homo sapiens
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Degrade xenobiotics, steroids
and fatty. Expressed in liver (about 13% of CYP enzymes). |
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Cytochrome P450 1B1 (CYP1B1) |
Homo sapiens
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Degrade xenobiotics, steroids
and fatty acids. Expressed in many tissues |
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Cytochrome P450 2A6 (CYP2A6) |
Homo sapiens
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Degrade
xenobiotics. Hydroxylation of some anti-cancer drugs. Expressed in liver |
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Cytochrome P450 2A7 (CYP2A7) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 2A13 (CYP2A13) |
Homo sapiens
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Degrade xenobiotics. Expressed
in liver and other tissues |
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Cytochrome P450 2B6 (CYP2B6) |
Homo sapiens
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Degrade xenobiotics,
steroids and fatty acids. Expressed in liver, lung and heart. |
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Cytochrome P450 2B7P1 (CYP2B7P1) |
Homo sapiens
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Monooxygenase |
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Cytochrome P450 2C8 (CYP2C8) |
Homo sapiens
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Degrade xenobiotics,
steroids and fatty acids. Metabolises anti-cancer drug taxol. |
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Cytochrome P450 2C9 (CYP2C9) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. Important in drug pharmacokinetics. |
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Cytochrome P450 2C18 (CYP2C18) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 2C19 (CYP2C19) |
Homo sapiens
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Degrade
xenobiotics, metabolising drugs such as anti-convulsants and barbiturates |
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Cytochrome P450 2D6 (CYP2D6) |
Homo sapiens
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Degrade
xenobiotics, metabolising drugs such as anti-arrhythmics, adrenoceptor
antagonists and tricyclic anti-depressants |
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Cytochrome P450 2E1 (CYP2E1) |
Homo sapiens
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Degrade
xenobiotics, including several precarcinogens, drugs and solvents to active
metabolites |
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Cytochrome P450 2F1 (CYP2F1) |
Homo sapiens
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Dealkylates some coumarin compounds |
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Cytochrome P450 2J2 (CYP2J2) |
Homo sapiens
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Fatty acid metabolism, especially arachidonic acid. Expressed primarily in heart |
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Cytochrome P450 2R1 (CYP2R1) (vitamin
D 25-hydrolase) |
Homo sapiens
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D-25-hydroxylase activity on both forms of vitamin D. Defects can cause pseudovitamin D-deficiency rickets |
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Cytochrome P450 2S1 (CYP2S1) |
Homo sapiens
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Degrades xenobiotics. Expressed in trachea, lung, spleen, small intestine, and stomach |
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Cytochrome P450 2U1 (CYP2U1) |
Homo sapiens
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Monooxygenase |
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Cytochrome P450 2W1 (CYP2W1) |
Homo sapiens
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Membrane protein |
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Cytochrome P450 3A3 (CYP3A3) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 3A4 (CYP3A4) |
Homo sapiens
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Degrade xenobiotics,
steroids and fatty acids. Expressed in prostate and liver. |
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Cytochrome P450 3A5 (CYP3A5) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 3A7 (CYP3A7) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 3A43 (CYP3A43) |
Homo sapiens
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Exhibits low
testosterone 6-beta-hydroxylase acitivity. Expressed mainly in prostate |
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Cytochrome P450 4A11 (CYP4A11) |
Homo sapiens
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Fatty acid
metabolism. Expressed in kidney and liver. |
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Cytochrome P450 4A22K (CYP4A22) |
Homo sapiens
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Monooxygenase |
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Cytochrome P450 4B1 (CYP4B1) |
Homo sapiens
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Degrade
xenobiotics, steroids and fatty acids. |
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Cytochrome P450 4F2 (CYP4F2) |
Homo sapiens
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Degrade xenobiotics,
steroids and fatty acids. Expressed in liver. |
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Cytochrome P450 4F3 (CYP4F3) |
Homo sapiens
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Omega-hydroxylation
of LTB4, a chemoattractant for leukocytes. Expressed in leukocytes. |
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Cytochrome P450 4F8 (CYP4F8) |
Homo sapiens
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Production
of 19R-hydroxy-prostaglandins in seminal fluids. Expressed mainly in seminal
vesicle |
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Cytochrome P450 4F11 (CYP4F11) |
Homo sapiens
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Flavoprotein
hydroxylation. Expressed mainly in liver. |
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Cytochrome P450 4F12 (CYP4F12) |
Homo sapiens
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Fatty acid
metabolism. Expressed in liver, small intestine, colon and heart. |
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Cytochrome P450 4V2 (CYP4V2) |
Homo sapiens
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Possibly involved
in fatty acid metabolism. Expressed in several tissues. |
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Cytochrome P450 4X1 (CYP4X1) |
Homo sapiens
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Flavoprotein
hydroxylation. |
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Cytochrome P450 4Z1 (CYP4Z1) |
Homo sapiens
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Flavoprotein
hydroxylation. Expressed in mammary gland (and breast carcinoma tissue) |
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Thromboxane-A synthase (CYP5A1) |
Homo sapiens
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Thromboxane synthesis. Expressed in platelets, lung,
kidney, spleen, macrophages and lung fibroblasts |
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Cytochrome P450 7A1 (CYP7A1) (cholesterol 7a‑monooxygenase) |
Homo sapiens
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Conversion of cholesterol to bile acids |
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Cytochrome P450 7B1 (CYP7B1) (oxysterol 7a‑hydroxylase) |
Homo sapiens
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Conversion of cholesterol to bile acids. Expressed in
brain, testes, ovary, prostate, liver, colon, kidney and small intestine |
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Prostacyclin
synthase (CYP8A1) |
Homo sapiens
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Catalyses isomerisation of prostaglandin H2 to
prostacyclin. Expressed in several tissues. |
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Cytochrome P450 8B1 (CYP8B1) |
Homo sapiens
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Steroid metabolism, including bile acid synthesis.
Expressed in liver. |
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Cytochrome P450 11A1 (CYP11A1),
mitochondrial |
Homo sapiens
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Catalyses side-chain cleavage reaction of cholesterol
pregnenolone. |
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Cytochrome P450 11B1 (CYP11B1),
mitochondrial |
Homo sapiens
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Steroid metabolism |
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Cytochrome P450 11B2 (CYP11B2),
mitochondrial |
Homo sapiens
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Steroid metabolism, especially production of aldosterone.
Defects cause adrenal hyperplasia type V |
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Cytochrome P450 17A1 (CYP17A1) |
Homo sapiens
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Steroid metabolism, especially the conversion of pregnenolone
and progesterone |
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Cytochrome P450 19A1 (CYP19A1) |
Homo sapiens
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Catalyses formation of aromatic C18 oestrogens and C19
androgens. Expressed in brain, gonads and placenta |
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Cytochrome P450, family 20, subfamily A, polypeptide 1 (CYP20A1) |
Homo sapiens
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Monooxygenase |
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Cytochrome P450 21 (CYP21A1) |
Homo sapiens
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Catalyses 21-hydroxylation of steroids; required for
adrenal synthesis of mineralocorticoids and glucocorticoids |
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Cytochrome P450 21‑hydroxylase (CYP21A2) |
Homo sapiens
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Monooxygenase |
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Cytochrome P450 24A1 (CYP24A1),
mitochondrial |
Homo sapiens
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Role in maintaining calcium homeostasis; vitamin D
hydroxylation |
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Cytochrome P450 26A1 (CYP26A1) (retinoic acid‑metabolizing cytochrome) |
Homo sapiens
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Retinoic acid metabolism. Expressed in adult liver, heart,
pituitary gland, adrenal gland, placenta and brain |
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Cytochrome P450 26B1 (CYP26B1) (retinoic acid‑metabolizing cytochrome) |
Homo sapiens
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Retinoic acid metabolism. Expressed in brain (cerebellum
and pons) |
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Cytochrome P450 26C1 (CYP26C1) |
Homo sapiens
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Retinoic acid metabolism. Expressed in several tissues |
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Cytochrome P450 27 (CYP27A1),
mitochondrial |
Homo sapiens
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Steroid metabolism, catalysing first step in oxidation of
side-chain of sterol intermediates |
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25‑hydroxyvitamin D‑1 alpha hydroxylase (CYP27B1), mitochondrial |
Homo sapiens
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Vitamin D3 metabolism; important for bone growth and
calcium metabolism. Expressed in kidney |
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Cytochrome P450 39A1 (CYP39A1) |
Homo sapiens
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Bile acid
metabolism. Expressed in liver |
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Cytochrome P450 46A1 (CYP46A1) (cholesterol 24‑hydrolase) |
Homo sapiens
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Cholesterol turnover. Expressed in brain |
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Cytochrome P450 51A1 (CYP51A1) |
Homo sapiens
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Cholesterol biosynthesis. Expressed in several tissues |
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