Amyloid-b Precursor Protein

This table contains entries for amyloid-b precursor protein, and its processing enzymes b-secretase and g-secretase, from different species in the UniProt database. Links are provided to view the original UniProtKB protein entries and their display in InterPro.

	UniProt	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match	Function
APP	A4_HUMAN (P05067)	Amyloid‑b A4 protein precursor (APP)	Homo sapiens			Neuronal cell surface receptor
	A4_PANTR (Q5IS80)	Amyloid‑b A4 protein precursor (APP)	Pan troglodytes Chimpanzee			Neuronal cell surface receptor
	A4_MACFA (P53601)	Amyloid‑b A4 protein precursor (APP)	Macaca fascicularis Crab-eating macaque			Neuronal cell surface receptor
	A4_MACMU (P29216)	Amyloid‑b A4 protein precursor (APP)	Macaca mulatta Rhesus macaque			Neuronal cell surface receptor
	A4_SAISC (Q95241)	Amyloid‑b A4 protein precursor (APP)	Saimiri sciureus Squirrel monkey			Neuronal cell surface receptor
	A4_PIG (P79307)	Amyloid‑b A4 protein precursor (APP)	Sus scrofia Pig			Neuronal cell surface receptor
	A4_CAVPO (Q60495)	Amyloid‑b A4 protein precursor (APP)	Cavia porcellus Guinea pig			Neuronal cell surface receptor
	A4_RAT (P08592)	Amyloid‑b A4 protein precursor (APP)	Rattus norvegicus Rat			Neuronal cell surface receptor
	A4_MOUSE (P12023)	Amyloid‑b A4 protein precursor (APP)	Mus musculus Mouse			Neuronal cell surface receptor
	A4_DROME (P14599)	Amyloid‑b A4 protein precursor (APP)	Drosophila melanogaster Fruitfly			Neuronal cell surface receptor
	A4_CAEEL (Q10651)	Amyloid‑b A4 protein precursor (APP)	Caenorhabditis elegans Nematode worm			Neuronal cell surface receptor
	A4_FUGRU (O93279)	Amyloid‑b A4 protein precursor (APP)	Fugu rubripes Japanese pufferfish			Neuronal cell surface receptor
	A4_TETFL (O73683)	Amyloid‑b A4 protein precursor (APP)	Tetraodon fluviatilis Puffer fish			Neuronal cell surface receptor
APP‑like	APLP1_HUMAN (P51693)	Amyloid-like protein 1 precursor (APLP-1)	Homo sapiens			May have post-synaptic function
	APLP2_HUMAN (Q06481)	Amyloid-like protein 2 precursor (APLP-2)	Homo sapiens			May help regulate haemostasis
	APLP1_MOUSE (Q03157)	Amyloid-like protein 1 precursor (APLP-1)	Mus musculus Mouse			May have post-synaptic function
	APLP2_MOUSE (Q06335)	Amyloid-like protein 2 precursor (APLP-2)	Mus musculus Mouse			May be involved in embryonic development
b‑secretase	BACE1_HUMAN (P56817)	Beta-secretase 1 precursor (EC 3.4.23.46)	Homo sapiens			Proteolytic processor of APP
	BACE2_HUMAN (Q9Y5Z0)	Beta-secretase 1 precursor (EC 3.4.23.45)	Homo sapiens			Proteolytic processor of APP
	BACE1_BOVIN (Q2HJ40)	Beta-secretase 1 precursor (EC 3.4.23.46)	Bos taurus Bovine			Proteolytic processor of APP
	BACE1_CAVPO (Q1KLR6)	Beta-secretase 1 precursor (EC 3.4.23.46)	Cavia porcellus Guinea pig			Proteolytic processor of APP
	BACE1_RAT (P56819)	Beta-secretase 1 precursor (EC 3.4.23.46)	Rattus norvegicus Rat			Proteolytic processor of APP
	BACE1_MOUSE (P56818)	Beta-secretase 1 precursor (EC 3.4.23.46)	Mus musculus Mouse			Proteolytic processor of APP
g‑secretase	APH1A_HUMAN (Q96BI3)	Gamma-secretase subunit APH-1A	Homo sapiens			Endoprotease
	APH1B_HUMAN (Q8WW43)	Gamma-secretase subunit APH-1B	Homo sapiens			Endoprotease
	APH1B_PONPY (Q5RDM3)	Gamma-secretase subunit APH-1B	Pongo pygmaeus Orangutan			Endoprotease
	APH1A_MOUSE (Q8BVF7)	Gamma-secretase subunit APH-1A	Mus musculus Mouse			Endoprotease
	APH1B_MOUSE (Q8C7N7)	Gamma-secretase subunit APH-1B	Mus musculus Mouse			Endoprotease
	APH1C_MOUSE (Q9DCZ9)	Gamma-secretase subunit APH-1C	Mus musculus Mouse			Endoprotease
	APH1B_BRARE (Q8JHE9)	Gamma-secretase subunit APH-1B	Brachydanio rerio Zebrafish			Endoprotease
	APH1_DROME (Q9VQG2)	Gamma-secretase subunit APH1	Drosophila melanogaster Fruitfly			Endoprotease
	APH1_CAEEL (O45876)	Gamma-secretase subunit APH1	Caenorhabditis elegans Nematode worm			Endoprotease
	APH1_ARATH (Q8L9G7)	Gamma-secretase subunit APH1-like	Arabidopsis thaliana Mouse‑ear cress			Endoprotease