Zinc Fingers
What InterPro Tells Us
P17842 Xenopus
Transcription Factor IIIA
InterPro Domain Architecture
InterPro Entry |
Signatures |
Graphical Match |
Method Name |
|
IPR007087 |
PF00096 |
|
Zf-C2H2 |
|
IPR007087 |
PS00028 |
|
Zn_finger_C2H2_1 |
|
IPR007087 |
PS50157 |
|
Zn_finger_C2H2_2 |
|
IPR007087 |
SM00355 |
|
ZnF_C2H2 |
|
Structural Predictions |
|
|
|
|
MB_P17842 |
|
|
|
|
SW_P17842 |
|
|
|
From the graphical match above, you can see that the signatures are all grouped into one InterPro entry for Xenopus transcription factor IIIA. IPR007087 represents the C2H2-type zinc finger domain, which is represented by four signatures: PF00096 from the PFAM database, PS00028 from the PROSITE patterns database, PS50157 from the PROSITE profile database, and SM00355 from the SMART database. As can be seen from the graphical view above, there are nine copies of this domain in transcription factor IIIA.
The remaining two entries in the table above give information on the predicted structure of this protein, where the ModBase homology model is represented by a yellow stripe, and the SwissModel homology model is represented by a red stripe. The ModBase model covers all nine zinc finger domains.
What the Structure Tells Us
The
homology model structures associated with Xenopus
TFIIIA are linked from the InterPro protein page for P17842. There are over 1000 structures available for various zinc
finger-containing proteins in the Protein Data Bank (PDB). A detailed description and visualisation of
the structural features of zinc finger proteins can be found at the PDB ‘Molecule of the Month’. The
crystallographic structures of various zinc finger-containing proteins have
provided insight into the different modes of binding of these important
proteins.