Zinc Fingers

This table contains entries for a few representative zinc finger proteins in the UniProt database. Links are provided to view the original UniProt protein entries and their display in InterPro.

	UniProt	Protein name	Organism	InterPro Domain Architecture	InterPro Graphical Match	Function
C2H2-type	TF3A_XENBO (P17842)	Transcription factor IIIA	Xenopus borealis Kenyan clawed frog			Transcription factor for 5S RNA genes
	ATF2_HUMAN (P15336)	Cyclic AMP-dependent transcription factor ATF-2	Homo sapiens			Activates cAMP-responsive element
	FOXP2_HUMAN (O15409)	Forkhead box protein P2	Homo sapiens			Transcriptional repressor
GATA_type	GATA1_HUMAN (P15976)	Erythroid transcription factor	Homo sapiens			Activates globin genes in erythroid cells
	MTA3_MOUSE (Q924K8)	Metastasis-associated protein MTA3	Mus musculus Mouse			Repression of SNAI1 transcription
	AREA_EMENI (P174297)	Nitrogen regulatory protein areA	Emericella nidulans Fungus			Nitrogen metabolite repression
RanBP‑type	RBP2_HUMAN (P49792)	E3 SUMO-protein ligase RanBP2	Homo sapiens			Facilitates SUMO1 and SUMO2 conjugation by UBE2I
	CAN15_HUMAN (O75808)	Calpain-15	Homo sapiens			Peptidase
	MDM2_HUMAN (Q00987)	Ubiquitin-protein ligase E3 Mdm2	Homo sapiens			Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis
A20‑type	ZFAN5_MOUSE (O88878)	AN1-type zinc finger protein 5	Mus musculus Mouse
	RABX5_HUMAN (Q9UJ41)	Rab5 GDP/GTP exchange factor	Homo sapiens			Rab effector protein
	SAP4_ARATH (Q9SJM6)	Zinc finger A20 and AN1 domain-containing stress-associated protein 4	Arabidopsis thaliana Mouse-ear cress			Environmental stress response
LIM‑type	LIN11_CAEEL (P20154)	Protein lin-11	Caenorhabditis elegans Nematode worm			Required for asymmetric division of vulval blast cells
	ISL1_HUMAN (P61371)	Insulin gene enhancer protein ISL-1	Homo sapiens			Binds insulin gene enhancer.
	MEC3_CAEEL (P09088)	Mechanosensory protein 3	Caenorhabditis elegans Nematode worm			Specifies differentiation of touch receptor neurons
MYND‑type	MTG8_HUMAN (Q06455)	Protein CBFA2T1	Homo sapiens			Transcription factor
	Q24037_DROME (Q24037)	Nervy	Drosophila melanogaster Fruit fly
	DEAF1_HUMAN (O75398)	Deformed epidermal autoregulatory factor 1 homolog	Homo sapiens			Binds promoter of HNRPA2B1 gene
RING‑type	MDM4_HUMAN (O15151)	Mdm4 protein	Homo sapiens			Inhibits p53- and p73-mediated cell cycle arrest and apoptosis
	BRCA1_RAT (O54952)	Breast cancer type 1 susceptibility protein homolog	Rattus norvegicus Rat			DNA repair
	CBL_HUMAN (P22681)	E3 ubiquitin-protein ligase CBL	Homo sapiens			Signal transduction in hematopoietic cells
PHD‑type	AIRE_HUMAN (O43918)	Autoimmune regulator	Homo sapiens			Transcription regulator
	TIF1B_HUMAN (Q13263)	Transcription intermediary factor 1-beta	Homo sapiens			Increases KRAB-mediated repression.
	PHF8_MOUSE (Q80TJ7)	PHD finger protein 8	Mus musculus Mouse
TAZ‑type	CBP_MOUSE (P45481)	CREB-binding protein	Mus musculus Mouse			Acetyltransferase enzyme
	EP300_HUMAN (Q09472)	Histone acetyltransferase p300	Homo sapiens			Histone acetyltransferase
	CBP1_CAEEL (P34545)		Caenorhabditis elegans Nematode worm			Acetyltransferase enzyme