focus

Interpro and rare diseases, an interesting example

Written on by Beatriz Lazaro Pinto/Sara Chuguransky
The 28th of February, the 29th in leap years, is the day to raise awareness of the over 5,000 rare diseases that affect millions of people worldwide.
Read More

Alphafold, A Novel Tool Shedding Light On Alzheimer’s Disease Proteins

Written on by Sara Chuguransky
Alzheimer’s disease (AD) is the most common type of dementia, affecting around 50 million patients worldwide.
Read More

The Beauty Of Domain Architecture And Evolution

Written on by Hsin-Yu Chang

Gene duplication serves as a major force in evolution. Duplicated genes can become a playground for evolution, and duplicates can split functions of the ancestral protein (subfuntionalization), or gain new functions (neofunctionalization). Sometimes they are mutated beyond rescue and become pseudogenes. Here we would like to demonstrate how InterPro can help researchers to navigate a particular group of duplicated proteins and their taxonomic distribution using their domain architecture. This can help us to understand how the protein evolved and diversified and help us to reach certain taxonomic groups that might be otherwise overlooked.

Read More

What's ape

Written on by Hsin-Yu Chang

The genus Homo, to which all human beings belong, is believed to have evolved from Australopithecus around 2–3 million years ago. Lucy, the Australopithecus afarensis ape, whose skeleton was pieced together from several hundred pieces of bone fossils, is the best known example of this genus. A gene duplication event that happened around 3.4 million years ago might have provided Lucy and her descendants with a boost to their brainpower.

Read More

Zika Virus and Microcephaly

Written on

You have probably been as horrified and saddened as me to see the shocking abnormality that affects newborn babies whose mothers have been infected with the Zika virus.

Read More

The Sweetest Thing

Written on by Hsin-Yu Chang

A famous cola company launched a new product contained in a gleaming green can last year. As a regular cola drinker, I was intrigued by the packaging. After doing some research, I discovered that this variety of cola contains a sweetener called Stevia.

Read More

Don’t Blame The Cat : The Toxoplasmosis Effect

Written on by Amaia Sangrador and Alex Mitchell

You may have heard about toxoplasmosis, or read about it in a newspaper or magazine. Toxoplasmosis is a condition caused by the protozoan Toxoplasma gondii, an intracellular parasite that infects a wide variety of warm-blooded animals, including humans. T. gondii has attracted the attention of both the scientific and lay communities, and with good reason. It is one of the most successful parasites, infecting over one third of the human population, with rates varying depending upon geographical location [1].

Read More

Dionysian Mysteries The Aldehyde Dehydrogenase (aldh) Family

Written on by Hsin-Yu Chang and Alex Mitchell

Do you have friends that cannot handle alcoholic drinks? Just half a pint of beer or a few sips of wine, and their faces turn red, possibly with some hangover symptoms, such as headaches and nausea? You may envy their cheap night out, but wonder why these people cannot tolerate alcohol as you do. The phenomenon is called ‘alcohol flush reaction’, also known as ‘Asian flush syndrome’, due to its association with the Asian population. It is a condition caused by the accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol.

Read More

Previous Interpro Protein Focus Articles

Written on

You can still find previous articles published to the InterPro blog in the “protein focus” category. They are archived and available in PDF format from this article.

Read More