Interpro 100: A Special Release

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Written on by Typhaine Paysan-Lafosse

This month we are celebrating the InterPro centenary release! It includes new features and improvements to the InterPro website. The list of changes is detailed in this post. If you have any feedback or suggestions, please contact us.

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Interpro 99.0: Updates

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Written on by Typhaine Paysan-Lafosse

This release includes new features and improvements to the InterPro website. The list of changes is detailed below. If you have any feedback or suggestions, please contact us.

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Interpro 98.0:updates

interpro
Written on by Typhaine Paysan-Lafosse

This release includes new features and improvements to the InterPro website. The list of changes is detailed below. If you have any feedback or suggestions, please contact us.

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Interpro And Intrinsically Disorder Proteins

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Written on by Luis Sanchez-Pulido

Structure is more conserved than sequence

As Linus Pauling, a double Nobel laureate (Peace 1962 and Chemistry 1954), stated, “If we want to understand cells, we must know their structure in terms of molecules” [1]. With this purpose in mind, to grasp the physiology of living organisms, we study proteins at the molecular level. To illuminate our path, we rely on the potent light shed by the evolutionary process, as nothing in biology makes sense except in the light of evolution [2].

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Interpro 97.0: Updates

interpro
Written on by Typhaine Paysan-Lafosse

This release includes new features and improvements to the InterPro website. The list of changes is detailed below. If you have any feedback or suggestions, please contact us.

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Interpro 89.0 Updates

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Written on by Typhaine Paysan-Lafosse, Gustavo A.Salazar

The latest release of InterPro comes with a number of improvements to the website. The list of changes is detailed below.

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Interpro 84.0 New And Updated Features

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Written on by Typhaine Paysan-Lafosse

The latest release of InterPro comes with a large number of improvements to the website. We hope that these changes large or small will make it easier for our users to find what they are looking for. We explain each of the changes in detail below.

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The Beauty Of Domain Architecture And Evolution

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Written on by Hsin-Yu Chang

Gene duplication serves as a major force in evolution. Duplicated genes can become a playground for evolution, and duplicates can split functions of the ancestral protein (subfuntionalization), or gain new functions (neofunctionalization). Sometimes they are mutated beyond rescue and become pseudogenes. Here we would like to demonstrate how InterPro can help researchers to navigate a particular group of duplicated proteins and their taxonomic distribution using their domain architecture. This can help us to understand how the protein evolved and diversified and help us to reach certain taxonomic groups that might be otherwise overlooked.

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Interpro 83.0 Key Features

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Written on by Typhaine Paysan-Lafosse

InterPro 83.0 has been released with plenty of new InterPro entries, but also with many new features and improvements. This blog post describes the new key features you can expect to encounter while navigating the InterPro website.

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Technical View Of The Interpro Client

interpro
Written on by Gustavo A. Salazar

In the last post we discussed the technical details of our API. We talked about how the website influenced some of the performance requirements of the API. The website, or for that matter any other client, was seen as a black box that created requests that the API needed to respond to. In this article we will switch those roles and delve into technical details of the web client, whilst treating the API as a black box that always responds to the client’s requests.

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New features in InterPro 82.0

interpro
Written on by Typhaine Paysan-Lafosse

InterPro 82.0 has been released with plenty of new InterPro entries, but also with many new features and improvements. This blog post describes the new key features you can expect to encounter while navigating the InterPro website.

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Homologous superfamily: a new InterPro entry type

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Written on

InterPro entries are comprised of one or more signatures from member databases, thereby providing a unified view of protein families. Each InterPro entry is labelled with a “type” reflecting what the constituent signatures represent: families, domains, repeats or sites. As part of release 65.0, InterPro has added a new entry type, homologous superfamily, to complement the existing set of types. A homologous superfamily is a group of proteins that share a common evolutionary origin, indicated by their structural similarities.

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What's ape

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Written on by Hsin-Yu Chang

The genus Homo, to which all human beings belong, is believed to have evolved from Australopithecus around 2–3 million years ago. Lucy, the Australopithecus afarensis ape, whose skeleton was pieced together from several hundred pieces of bone fossils, is the best known example of this genus. A gene duplication event that happened around 3.4 million years ago might have provided Lucy and her descendants with a boost to their brainpower.

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InterPro's new skin

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Written on

Those of you with sharp eyes may have noticed some minor changes to the InterPro web site as we have moved to adopt EMBL-EBI’s new site guidelines.

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New entries in InterPro 61 - the tip of the iceberg

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Written on

iceberg image The thing about icebergs is, with 90% of their volume hidden beneath the water, it can be hard to appreciate their true size. The same can be said about InterPro 61.0, which represents a real iceberg of a release, with a huge amount of unseen work below the surface that is not fully reflected in the release note statistics.

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Zika Virus and Microcephaly

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Written on

You have probably been as horrified and saddened as me to see the shocking abnormality that affects newborn babies whose mothers have been infected with the Zika virus.

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The Sweetest Thing

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Written on by Hsin-Yu Chang

A famous cola company launched a new product contained in a gleaming green can last year. As a regular cola drinker, I was intrigued by the packaging. After doing some research, I discovered that this variety of cola contains a sweetener called Stevia.

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Don’t Blame The Cat : The Toxoplasmosis Effect

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Written on by Amaia Sangrador and Alex Mitchell

You may have heard about toxoplasmosis, or read about it in a newspaper or magazine. Toxoplasmosis is a condition caused by the protozoan Toxoplasma gondii, an intracellular parasite that infects a wide variety of warm-blooded animals, including humans. T. gondii has attracted the attention of both the scientific and lay communities, and with good reason. It is one of the most successful parasites, infecting over one third of the human population, with rates varying depending upon geographical location [1].

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Dionysian Mysteries The Aldehyde Dehydrogenase (aldh) Family

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Written on by Hsin-Yu Chang and Alex Mitchell

Do you have friends that cannot handle alcoholic drinks? Just half a pint of beer or a few sips of wine, and their faces turn red, possibly with some hangover symptoms, such as headaches and nausea? You may envy their cheap night out, but wonder why these people cannot tolerate alcohol as you do. The phenomenon is called ‘alcohol flush reaction’, also known as ‘Asian flush syndrome’, due to its association with the Asian population. It is a condition caused by the accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol.

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