InterPro entries are comprised of one or more signatures from member databases, thereby providing a unified view of protein families. Each InterPro entry is labelled with a “type” reflecting what the constituent signatures represent: families, domains, repeats or sites. As part of release 65.0, InterPro has added a new entry type, homologous superfamily, to complement the existing set of types. A homologous superfamily is a group of proteins that share a common evolutionary origin, indicated by their structural similarities.

The genus Homo, to which all human beings belong, is believed to have evolved from Australopithecus around 2–3 million years ago. Lucy, the Australopithecus afarensis ape, whose skeleton was pieced together from several hundred pieces of bone fossils, is the best known example of this genus. A gene duplication event that happened around 3.4 million years ago might have provided Lucy and her descendants with a boost to their brainpower.

Those of you with sharp eyes may have noticed some minor changes to the InterPro web site as we have moved to adopt EMBL-EBI’s new site guidelines.

The thing about icebergs is, with 90% of their volume hidden beneath the water, it can be hard to appreciate their true size. The same can be said about InterPro 61.0, which represents a real iceberg of a release, with a huge amount of unseen work below the surface that is not fully reflected in the release note statistics.

We are pleased to announce that the NCBI Conserved Domain Database (CDD) has joined the InterPro consortium as a member database, and has begun to be integrated into the resource.

You have probably been as horrified and saddened as me to see the shocking abnormality that affects newborn babies whose mothers have been infected with the Zika virus.

The removal of annotation from biological databases is often taken to mean that the annotation was wrong in the first place. Why else would diligent biocuators remove information that had been painstakingly added to database entries?

You can still find previous articles published to the InterPro blog. Bear in mind that these are older articles and might be out of date. Find them on Blogspot.

A famous cola company launched a new product contained in a gleaming green can last year. As a regular cola drinker, I was intrigued by the packaging. After doing some research, I discovered that this variety of cola contains a sweetener called Stevia.

You may have heard about toxoplasmosis, or read about it in a newspaper or magazine. Toxoplasmosis is a condition caused by the protozoan Toxoplasma gondii, an intracellular parasite that infects a wide variety of warm-blooded animals, including humans. T. gondii has attracted the attention of both the scientific and lay communities, and with good reason. It is one of the most successful parasites, infecting over one third of the human population, with rates varying depending upon geographical location [1].

Do you have friends that cannot handle alcoholic drinks? Just half a pint of beer or a few sips of wine, and their faces turn red, possibly with some hangover symptoms, such as headaches and nausea? You may envy their cheap night out, but wonder why these people cannot tolerate alcohol as you do. The phenomenon is called ‘alcohol flush reaction’, also known as ‘Asian flush syndrome’, due to its association with the Asian population. It is a condition caused by the accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol.

You can still find previous articles published to the InterPro blog in the “protein focus” category. They are archived and available in PDF format from this article.