InterPro entries are comprised of one or more signatures from member databases, thereby providing a unified view of protein families. Each InterPro entry is labelled with a “type” reflecting what the constituent signatures represent: families, domains, repeats or sites. As part of release 65.0, InterPro has added a new entry type, homologous superfamily, to complement the existing set of types. A homologous superfamily is a group of proteins that share a common evolutionary origin, indicated by their structural similarities.
Those of you with sharp eyes may have noticed some minor changes to the InterPro web site as we have moved to adopt EMBL-EBI’s new site guidelines.
The thing about icebergs is, with 90% of their volume hidden beneath the water, it can be hard to appreciate their true size. The same can be said about InterPro 61.0, which represents a real iceberg of a release, with a huge amount of unseen work below the surface that is not fully reflected in the release note statistics.
The removal of annotation from biological databases is often taken to mean that the annotation was wrong in the first place. Why else would diligent biocuators remove information that had been painstakingly added to database entries?
You can still find previous articles published to the InterPro blog. Bear in mind that these are older articles and might be out of date. Find them on Blogspot.